Journal
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
Volume 27, Issue 2, Pages 354-358Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ja10289c
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Funding
- Fundacio Caixa Castello-Bancaixa [PB1-1B2009-29]
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In the present work, internal standardization based on species-unspecific isotope dilution analysis technique is proposed in order to overcome the matrix effects and signal drift originated in the speciation of As in urine by HPLC-ICP-MS. To this end, Ge-72 has been selected as a pseudo-isotope of As. The resulting mass flow chromatogram of the element allows the calculation of the corrected overall species concentrations without requiring any methodological calibration, providing high-throughput sample processing. The validation was carried out by analyzing a blank human urine fortified at three concentration levels and an unspiked human urine sample containing different species of arsenic. In all cases, recoveries ranging from 90 to 115% and RSD below 10% were attained with this approach. Furthermore, the proposed method provided results in excellent agreement with those obtained using standard additions and internal standard calibration, allowing a fast way to assess human exposure to arsenic species.
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