Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 38, Issue 1, Pages 171-184Publisher
IOS PRESS
DOI: 10.3233/JAD-130098
Keywords
Alzheimer's disease; amyloid-beta; brain imaging; mild cognitive impairment; molecular imaging; neurofibrillary tangles; PHF-tau; tau; tau aggregates; tauopathy
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Funding
- Siemens Medical Solutions USA, Inc.
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Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have recently reported early clinical results of a novel PHF-tau targeting PET imaging agent, [F18]-T807. Since then, we have investigated a second novel PHF-tau targeting PET imaging agent, [ F18]-T808, with different pharmacokinetic characteristics, which may be favorable for imaging Alzheimer's disease and other tauopathies. Here, we describe the first human brain images with [F18]-T808.
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