Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 24, Issue 4, Pages 615-631Publisher
IOS PRESS
DOI: 10.3233/JAD-2011-101908
Keywords
Age-related macular degeneration (AMD); aggregation; aging; Alzheimer's disease; autophagy; lysosome; oxidative stress; proteasome
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Funding
- Kuopio University Hospital [5772708, 5503726]
- Finnish Cultural Foundation
- North Savo Fund
- Finnish Eye Foundation
- Finnish Funding Agency for Technology and Innovation, Health Research Council of the Academy of Finland
- Nordic Centre of Excellence in Neurodegeneration
- Paivikki and Sakari Sohlberg Foundation
- Sigrid Juselius Foundation
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Age-related macular degeneration (AMD) is a late-onset, neurodegenerative retinal disease that shares several clinical and pathological features with Alzheimer's disease (AD), including stress stimuli such as oxidative stress and inflammation. In both diseases, the detrimental intra- and extracellular deposits have many similarities. Aging, hypercholesterolaemia, hypertension, obesity, arteriosclerosis, and smoking are risk factors to develop AMD and AD. Cellular aging processes have similar organelle and signaling association in the retina and brain tissues. However, it seems that these diseases have a different genetic background. In this review, differences and similarities of AMD and AD are thoroughly discussed.
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