Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 26, Issue -, Pages 287-296Publisher
IOS PRESS
DOI: 10.3233/JAD-2011-0007
Keywords
Alzheimer's disease; mild cognitive impairment; white matter; diffusion tensor imaging; clinical application
Categories
Funding
- NIH (Johns Hopkins Alzheimer's Disease Research Center) [R21AG033774, P41RR015241, U24RR021382, PO1EB00195, RO1AG20012, P50AG005146]
- Glaxo-Smith-Kline
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR015241, U24RR021382] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG020012, P50AG005146, R21AG033774] Funding Source: NIH RePORTER
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DTI is one of the most effective MR tools for the investigation of the brain anatomy. In addition to the gray matter, histopathological studies indicate that white matter is also a good target for both the early diagnosis of AD and for monitoring disease progression, which motivates us to use DTI to study AD patients in vivo. There are already a large amount of studies reporting significant differences between AD patients and controls, as well as to predict progression of disease in symptomatic non-demented individuals. Application of these findings in clinical practice remains to be demonstrated.
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