Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 27, Issue 3, Pages 477-482Publisher
IOS PRESS
DOI: 10.3233/JAD-2011-110650
Keywords
Alzheimer's disease; cognitive disorder; cognitive flexibility; dopamine; excitotoxicity; GABA(A); hippocampus; learning and memory; memantine; mental flexibility; mice; mouse; muscarinic cholinergic system; neurotoxicity; NMDAR; platform re-location water maze; prefrontal cortex
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Funding
- Canadian Institute of Health Research (CIHR)
- Nickel-a-Drink Foundation
- Bank of Montreal
- James F. Crothers Foundation
- Margaret and Howard Gamble Foundation
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Alzheimer's disease (AD) is multi-factorial mental disorder characterized by a copious array of congruent features cumulating in disrupted memory and dysthymia. Though the mechanism remains elusive, the highly unspecific pharmaceutical, memantine, provides modest benefits for patients with moderate-to-severe AD. A greater understanding of how memantine affects cognitive function promises to facilitate the search for better therapeutics. We therefore examined cognitive flexibility of mice following 5 and 10 mg/kg memantine administration using a platform re-location water maze. Strikingly, subjects receiving memantine demonstrated memory impairment relative to controls when re-trained off drug, revealing a novel and unusual disruption of cognitive flexibility.
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