Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 20, Issue -, Pages S357-S367Publisher
IOS PRESS
DOI: 10.3233/JAD-2010-100498
Keywords
Apoptosis; autophagy; mitochondria; neurodegeneration; reactive oxygen species
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Funding
- Canadian Institutes of Health Research (CIHR)
- Parkinson's Research Consortium
- Parkinson's Society of Canada
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Neuronal cell loss associated with neurodegeneration has recently been linked to mitochondrial dysfunction. Electron transport chain defects and reactive oxygen species (ROS) production are emerging as important players in the etiology of neurodegenerative diseases. Proper management of ROS and disposal of damaged cellular components are vital to the survival and function of neurons. Proteins involved in these pathways are often mutated in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease. In this review, we will discuss the roles of ROS in normal physiology, how changes in ROS production affect neuronal survival in neurodegenerative diseases, and the recent advances in mitochondrial antioxidants as potential therapeutics.
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