Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 19, Issue 4, Pages 1143-1148Publisher
IOS PRESS
DOI: 10.3233/JAD-2010-1309
Keywords
Disease progression; early Alzheimer's disease; Eta-1; microglia; neuroinflammation
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Funding
- Compagnia di San Paolo (Turin)
- Regione Piemonte Ricerca Finalizzata
- Ricerca Applicata CIPE
- FISM [2008/R/11]
- AIRC
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Inflammation is believed to play a role in Alzheimer's disease (AD). Osteopontin (OPN) is a molecule involved in macrophage recruitment and activation and implicated in neurodegeneration. In order to elucidate the role of OPN in AD, we evaluated its levels in serum and cerebrospinal fluid (CSF) of 67 AD patients, 46 frontotemporal dementia (FTD) patients, and 69 controls. We found that OPN levels: i) are significantly increased in the CSF of AD patients; ii) correlate with MMSE score; and iii) are higher in the early disease phases (<= 2 years). These findings support a role of OPN in AD pathogenesis.
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