Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 19, Issue 3, Pages 1035-1040Publisher
IOS PRESS
DOI: 10.3233/JAD-2010-1300
Keywords
Alzheimer's disease; artificial neural networks; biological markers; mild cognitive impairment
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Funding
- Bracco Pharma Italy
- Italian Minister of Health
- Fondazione CARIGE
- Fondazione CARIPLO
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The search for markers that are able to predict the conversion of amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD) is crucial for early mechanistic therapies. Using artificial neural networks (ANNs), 22 variables that are known risk factors of AD were analyzed in 80 patients with aMCI, for a period spanning at least 2 years. The cases were chosen from 195 aMCI subjects recruited by four Italian Alzheimer's disease units. The parameters of glucose metabolism disorder, female gender, and apolipoprotein E epsilon 3/epsilon 4 genotype were found to be the biological variables with high relevance for predicting the conversion of aMCI. The scores of attention and short term memory tests also were predictors. Surprisingly, the plasma concentration of amyloid-beta(42) had a low predictive value. The results support the utility of ANN analysis as a new tool in the interpretation of data from heterogeneous and distinct sources.
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