Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 22, Issue 1, Pages 247-255Publisher
IOS PRESS
DOI: 10.3233/JAD-2010-100933
Keywords
Age at onset; Alzheimer's disease; apolipoprotein E; CALHM1; polymorphism
Categories
Funding
- National Foundation for Alzheimer's disease and related disorders
- Institut Pasteur de Lille
- Centre National de Genoty page
- Fondation pour la Recherche Medicale
- French Ministry of Research/INSERM
- Eisai
- VIB Genetic Service Facility
- Biobank of the Institute Born-Bunge
- University of Antwerp
- Fund for Scientific Research-Flanders (FWO-V)
- Foundation for Alzheimer Research (SAOFRMA)
- Belgian Federal Science Policy Office
- Belgium [P6/43]
- Health Research Council of the Academy of Finland, Kuopio University Hospital [5772708]
- Nordic Centre of Excellence in Neurodegeneration
- Italian Ministry of research and University
- Carimonte Foundation
- Sanpaolo [1070IT/CV2007.0548]
- Fondazione Cassa di resparmio di Pistoia e pescia [2009.0220]
- Fondazione Monzino
- Italian Ministry of Health
- Italian Ministry of Health (Progetti di Ricerca Finalizzati)
- Ministerio de Educacion y Ciencia
- Ministerio de Sanidad y Consumo (Instituto de Salud CarlosIII)
- Fundacion Alzheimur (Murcia)
- Ministerio de Educacion y Ciencia (Gobierno de Espana) [PCT-010000-2007-18]
- USA National Institute on Aging (NIA) [AG030653, AG005133, AG20135, AG19757]
- National Institute of Neurological Disorders and Stroke [NS31153]
- Alzheimer's Association
- Institut de France
- Aquitaine and Bourgogne Regional Councils, Fondation de France
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS031153] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG030653, P50AG005133, R01AG019757, R01AG020135] Funding Source: NIH RePORTER
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The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the epsilon 4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the epsilon 4 allele of the APOE gene.
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