Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 16, Issue 4, Pages 787-808Publisher
IOS PRESS
DOI: 10.3233/JAD-2009-0973
Keywords
Alzheimer's disease; energy homeostasis; insulin signaling; metabolic syndrome; transcription; type 2 diabetes
Categories
Funding
- Deutsche Forschungsgemeinschaft
- Thyssen Foundation
- Network Aging Research Heidelberg/Mannheim
- European Foundation for the Study of Diabetes
- Novartis Foundation for Therapeutic Research
- Marie Curie Excellence Grant (European Union)
Ask authors/readers for more resources
Numerous epidemiological and experimental studies have established a strong connection between type 2 diabetes and the risk of the development of Alzheimer's disease. Indeed, several pathological features have been identified as common denominators of diabetic and Alzheimer's patients, including insulin resistance, dyslipidemia and inflammation, suggesting a close connection between the two disorders. Here we review common metabolic and inflammatory processes implicated in the pathogenesis of both disorders. In particular, the role of critical transcriptional checkpoints in the control of cellular metabolism, insulin sensitivity, and inflammation will be emphasized in this context. These transcriptional regulators hold great promise as new therapeutic targets in the potentially combined treatment of type 2 diabetes and Alzheimer's disease in the future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available