Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 16, Issue 3, Pages 619-626Publisher
IOS PRESS
DOI: 10.3233/JAD-2009-1003
Keywords
Alzheimer's disease; anesthesia; phosphorylation; tau; tau kinases; tau phosphatases
Categories
Funding
- NIH [AG027429, AG019158]
- U. S. Alzheimer's Association [IIRG-05-13095]
- NSFC [30500475, 30701092]
- NATIONAL INSTITUTE ON AGING [R01AG019158, R01AG027429] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Abnormal hyperphosphorylation and aggregation of microtubule-associated protein tau play a crucial role in neurodegeneration of Alzheimer's disease (AD). Anesthesia has been associated with cognitive impairment and the risk for AD. Here we investigated the effects of anesthesia on site-specific tau phosphorylation and the possible mechanisms. We found that anesthesia for short periods (30 sec to 5 min) induced tau phosphorylation at Thr181, Ser199, Thr205, Thr212, Ser262, and Ser404 to small, but significant, extents, which appeared to result from anesthesia-induced activation of stress-activated protein kinases. Anesthesia for a longer time (1 h) induced much more dramatic phosphorylation of tau at the above sites, and the further phosphorylation may be associated with hypothermia induced by anesthesia. Anesthesia-induced tau phosphorylation appears to be specific because the increased phosphorylation was only seen at half of the tau phosphorylation sites studied and was not observed in global brain proteins. These studies clarified the dynamic changes of tau phosphorylation at various sites and, thus, served as a fundamental guide for future studies on tau phosphorylation by using brains of anesthetized experimental animals. Our findings also provide a possible mechanism by which anesthesia may cause postoperative cognitive impairment and increase the risk for AD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available