Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 18, Issue 3, Pages 703-711Publisher
IOS PRESS
DOI: 10.3233/JAD-2009-1180
Keywords
Aging; community-based; microinfarct; longitudinal; neuropathology
Categories
Funding
- NIA NIH HHS [U01 AG006781, R01 AG023801] Funding Source: Medline
- NINDS NIH HHS [R01 NS048595] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS048595] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [U01AG006781, R01AG023801] Funding Source: NIH RePORTER
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The neuropathology underlying dementia syndromes in older populations is complex. The contributions of Alzheimer's and Lewy body pathology are well appreciated. Recent studies with brain autopsies have highlighted the high prevalence of vascular disease as an independent, but often co-morbid contributor to dementia. The Adult Changes in Thought Study is a community-based, longitudinal study of brain aging and cognitive decline which has recently confirmed cerebral microinfarcts as a strong correlate of cognitive impairment and dementia. This study examines correlations between clinical characteristics including extensive, longitudinal medication histories, and longitudinal cognitive testing against structural and biochemical features of disease.
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