Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 16, Issue 3, Pages 471-483Publisher
IOS PRESS
DOI: 10.3233/JAD-2009-0992
Keywords
Amyloid-beta; early Alzheimer's disease; mild cognitive impairment; zinc; zinc transport proteins
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Funding
- NIH [1R01-AG16269, 5-P01AG05119, 1P30-AG028383]
- Abercrombie Foundation
- NATIONAL INSTITUTE ON AGING [P01AG005119, P30AG028383, R01AG016269] Funding Source: NIH RePORTER
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Although multiple studies have suggested a role for alterations of zinc (Zn) and zinc transport (ZnT) proteins in the pathogenesis of Alzheimer's disease, the exact role of this essential trace element in the progression of the disease remains unclear. The following review discusses the normal role of Zn and ZnT proteins in brain and the potential effects of their alteration in the pathogenesis of Alzheimer's disease, particularly in the processing of the amyloid-beta protein precursor and amyloid-beta peptide generation and aggregation.
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