Journal
NANOSCALE
Volume 7, Issue 10, Pages 4274-4290Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr05697c
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Funding
- 973 program of MOST of China [2014CB845605]
- Special Project of National Major Scientific Equipment Development of China [2012YQ120060]
- NSFC [31161130356, 11204302, 11304314, U1305244, U1405229, 21325104]
- CAS/SAFEA International Partnership Program for Creative Research Teams
- Strategic Priority Research Program and Scientific Equipment Development Project of the CAS [XDA09030307, YZ201210]
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Sensitive and specific biodetection of tumor markers is essential for early-stage cancer diagnosis and therapy, and will ultimately increase the patient survival rate. As a new generation of luminescent bioprobes, lanthanide (Ln(3+))-doped inorganic luminescent nanoparticles have attracted considerable interest for a variety of biomedical applications due to their superior physicochemical properties. In this feature article, we provide a brief overview of the most recent advances in the development of Ln(3+)-doped luminescent nano-bioprobes and their promising applications for in vitro detection of tumor markers with an emphasis on the establishment of state-of-the-art assay techniques, such as heterogeneous timeresolved (TR) luminescent bioassay, dissolution-enhanced luminescent bioassay, upconversion (UC) luminescent bioassay, homogeneous TR Forster resonance energy transfer (TR-FRET) and UC-FRET bioassays. Some future prospects and efforts towards this emerging field are also envisioned.
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