Journal
NANOSCALE
Volume 7, Issue 8, Pages 3381-3391Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr07677j
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Funding
- Joint Department of Biomedical Engineering at University of North Carolina at Chapel Hill
- Joint Department of Biomedical Engineering at North Carolina State University
- NC State
- NC TraCS [550KR51307]
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Recent developments in nanomedicine for the cancer therapy have enabled programmable delivery of therapeutics by exploiting the stimuli-responsive properties of nanocarriers. These therapeutic systems were designed with the relevant chemical and physical properties that respond to different triggers for enhanced anticancer efficacy, including the reduced development of drug-resistance, lower therapeutic dose, site-specific transport, and spatiotemporally controlled release. This minireview discusses the current advances in programmable nanocarriers for cancer therapy with particular emphasis on synergistic and sequential drug delivery systems.
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