Journal
NANOSCALE
Volume 7, Issue 45, Pages 19066-19072Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr05362e
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Funding
- Fundamental Research Funds for the Central Universities [XDJK2015A005, XDJK2016D033]
- Research Fund for the Doctoral Program of Higher Education of China [20110182120014]
- Natural Science Foundation Project of CQ CSTC [cstc2013jcyjA10117]
- Innovative Research Project for Postgraduate Students of Chongqing [CYS14049]
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Herein, papain-functionalized Cu nanoclusters (CuNCs@Papain) were originally synthesized in aqueous solution together with a quantum yield of 14.3%, and showed obviously red fluorescence at 620 nm. Meanwhile, their corresponding fluorescence mechanism was fully elucidated by fluorescence spectroscopy, HR-TEM, FTIR spectroscopy, and XPS. Subsequently, the as-prepared CuNCs were employed as probes for detecting H2O2. Using CuNCs as probes, H2O2 was determined in the range from 1 mu M to 50 mu M based on a linear decrease of fluorescence intensity as well as a detection limit of 0.2 mu M with a signal-to-noise ratio of 3. More significantly, it has been proved that CuNCs could convert H2O2 to (OH)-O-center dot, which exhibited dramatic antibacterial activity. Both in vitro and in vivo experiments were performed to validate their antibacterial activity against Gram-positive/negative bacteria and actual wound infection, suggesting their potential for serving as one type of promising antibacterial material.
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