Biocompatible polymer composites based on ultrahigh molecular weight polyethylene perspective for cartilage defects replacement

The purpose of this study was to evaluate mechanical properties, microstructure and biocompatibility of nano-compounds obtained by mechanical activation of UHMWPE powder and several types of particulate fillers in a planetary ball mill. The effect of particle shape and concentration of Al2O3 on properties of the composite was investigated. The effectiveness of reinforcing a polyethylene matrix by mechanoactivated alumina in the form of nanopowder or microspheres was shown. Reinforcing of the polymer by nanoparticles significantly improves wear-resistance. No signs of blood serum fibrin deposition on the surface of the samples were observed. Also no signs of pathological changes in physiology or anatomy were noticed on the animals with implanted samples. UHMWPE-based composites obtained by mechanical activation and hot pressing and filled with ceramic particles can be used as a biocompatible material for the replacement of cartilage. (C) 2012 Elsevier B. V. All rights reserved.