Journal
NANOSCALE
Volume 7, Issue 43, Pages 18044-18048Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr04688b
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Funding
- National Natural Science Foundation of China [81503086]
- Tianjin University of Science Technology [20140520]
- Foundation of Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education
- Tianjin Key Lab of Industrial Microbiology [2015IM106]
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We constructed a reversible molecular device in the nanoscale based on a DNA three-way junction (3WJ) fueled by Hg2+ binding and sequestration. It is highly responsive to external stimuli, which brings about optically detectable global structural changes. Such a DNA device can serve as a novel turn-on and -off fluorescent sensor for Hg2+ and biothiol detection with high selectivity and sensitivity.
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