4.8 Article

Design and assembly of supramolecular dual-modality nanoprobes

Journal

NANOSCALE
Volume 7, Issue 21, Pages 9462-9466

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr01518a

Keywords

-

Funding

  1. National Science Foundation [DMR 1255281]
  2. National Institutes of Health [U54CA151838]
  3. W. W. Smith Charitable Trust

Ask authors/readers for more resources

We report the design and synthesis of self-assembling dual-modality molecular probes containing both a fluorophore for optical imaging and a metal ion chelator for imaging with MRI or radionuclide methods. These molecular probes can spontaneously associate into spherical nanoparticles under physiological conditions. We demonstrate the use of these supramolecular nano-probes for live-cell optical imaging, as well as their potential use as MRI contrast agents after complexation with gadolinium. Our results suggest that self-assembly into supramolecular nanoprobes presents an effective means to enhance and tune the relaxivities of molecular probes.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available