Journal
NANOSCALE
Volume 7, Issue 21, Pages 9462-9466Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr01518a
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Funding
- National Science Foundation [DMR 1255281]
- National Institutes of Health [U54CA151838]
- W. W. Smith Charitable Trust
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We report the design and synthesis of self-assembling dual-modality molecular probes containing both a fluorophore for optical imaging and a metal ion chelator for imaging with MRI or radionuclide methods. These molecular probes can spontaneously associate into spherical nanoparticles under physiological conditions. We demonstrate the use of these supramolecular nano-probes for live-cell optical imaging, as well as their potential use as MRI contrast agents after complexation with gadolinium. Our results suggest that self-assembly into supramolecular nanoprobes presents an effective means to enhance and tune the relaxivities of molecular probes.
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