Journal
NANOSCALE
Volume 7, Issue 3, Pages 889-895Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr05576d
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Funding
- Nanyang Technological University
- AcRF Tier 1 from the Ministry of Education, Singapore [RG49/12]
- AcRF Tier 2 from the Ministry of Education, Singapore [ARC 36/13, ARC 22/13]
- Singapore Centre on Environmental Life Sciences Engineering (SCELSE) [M4330005.C70]
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We report a facile and general strategy for enhancing the photostability of organic fluorophores for bioimaging applications. As a proof of concept, bright and robust fluorescence was observed in solid states of a well-defined synthetic polymer polycaprolactone consisting of di(thiophene-2-yl)-diketopyrrolopyrrole covalently linked in the middle of the polymer chain as a biocompatible and bioresorbable matrix. The nanoparticles prepared through a nano-precipitation process of these polymers could be internalized by both tumor cells and stem cells with little cytotoxicity. Moreover, these highly fluorescent nanoparticles exhibited significantly enhanced photostability compared to commercial quantum dots or physical blends of dye/polymer complexes in cell imaging and long-term tracing.
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