4.8 Article

Magnetic field activated drug delivery using thermodegradable azo-functionalised PEG-coated core-shell mesoporous silica nanoparticles

Journal

NANOSCALE
Volume 7, Issue 31, Pages 13168-13172

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr03777h

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Funding

  1. U.S. National Institutes of Health NIH [R01 CA133697]
  2. Department of Defense [HDTRA-1-13-1-0046]
  3. NIH [1-DP2-OD008533]

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Core-shell Fe3O4@SiO2 mesoporous silica nanoparticles coated with a new thermodegradable polymer allowed the release of a model drug through heating caused by a high frequency oscillating magnetic field. The thermodegradable polymer was made of poly(ethylene glycol) (PEG) functionalised with azo bonds that break with an elevation of temperature.

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