Journal
NANOSCALE
Volume 7, Issue 2, Pages 415-420Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr02776k
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Funding
- GACR [P108/12/0640]
- MSMT [LM2011019]
- NPU I from Ministry of Education, Youth and Sports [LO 1302]
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Core-shell nanoparticles based on fluorescent nanodiamonds coated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer shell were developed for background-free near-infrared imaging of cancer cells. The particles showed excellent colloidal stability in buffers and culture media. After conjugation with a cyclic RGD peptide they selectively targeted integrin alpha(v)beta(3) receptors on glioblastoma cells with high internalization efficacy.
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