Journal
NANOSCALE
Volume 7, Issue 2, Pages 440-444Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr05269b
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Funding
- National Institutes of Health NHLBI Program of Excellence in Nanotechnology [HHSN268201000046]
- Washington University Molecular Imaging Center (NCI) [P50 CA094056]
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A gold nanoparticle was radiolabeled with I-125 and In-111 and functionalized with an MMP9-cleavable peptide to form a multispectral SPECT imaging contrast agent. Peptide cleavage from the nanoprobe by MMP9 was observed in vitro, and distinct pharmacokinetic properties of the contrast agent were observed between tumors with high or low MMP9 expression.
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