Journal
NANOSCALE
Volume 7, Issue 18, Pages 8574-8583Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr00829h
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [NSFC 51332008, 51372243, 51422209, 51202239]
- National Basic Research Program of China [2014CB643803]
Ask authors/readers for more resources
Core-shell structured Nd3+-sensitized NaYF4:Yb/Nd/Er@NaYF4:Nd@mSiO(2) nanoparticles (NPs) were designed and synthesized. The NaYF4:Yb/Nd/Er@NaYF4:Nd core imparts the nanomaterials with luminescence properties for upconversion optical imaging under 808 nm laser irradiation, whereas the mesoporous SiO2 shell allows the nanomaterials to be loaded with anticancer drug doxorubicin (DOX). In vivo toxicity assessment has confirmed that the NPs have low systematic toxicity in healthy mice. In vivo antitumor activity shows that the nanocomposites exhibit greater antitumor efficacy than pure DOX. As a result, the composite nanomaterials can serve as nanotheranostic materials for synchronous upconversion luminescence imaging under 808 nm laser irradiation, and as anticancer drug delivery vehicles, so as to integrate the diagnosis and treatment of cancers in vivo.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available