4.8 Article

An easy-to-prepare mini-scaffold for DNA origami

Journal

NANOSCALE
Volume 7, Issue 40, Pages 16621-16624

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr04921k

Keywords

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Funding

  1. US National Science Foundation [EPMD-1231888, IRES-1246799]
  2. MolPhysX program at the University of Copenhagen
  3. Dansk Olie og Naturgas
  4. DGAPA-UNAM [IN105513-2]
  5. CONACYT [CB-176352]
  6. Div Of Electrical, Commun & Cyber Sys
  7. Directorate For Engineering [1231888] Funding Source: National Science Foundation

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The DNA origami strategy for assembling designed supramolecular complexes requires ssDNA as a scaffold strand. A system is described that was designed approximately one third the length of the M13 bacteriophage genome for ease of ssDNA production. Folding of the 2404-base ssDNA scaffold into a variety of origami shapes with high assembly yields is demonstrated.

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