Journal
NANOSCALE
Volume 7, Issue 29, Pages 12419-12426Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr02240a
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Funding
- National Basic Research Program of China [2012CB720602, 2011CB936004]
- National Natural Science Foundation of China [21210002, 91213302, 91413111, 21431007]
- Jilin Province Science and Technology Development Plan Project [20140414019GH]
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We here report a facile one-pot synthesis of fluorescent gold nanoclusters (AuNCs) via the peptide bio-mineralization method, which can elicit specific immunological responses. The as-prepared peptide-protected AuNCs (peptide-AuNCs) display strong red fluorescence, and more importantly, as compared to the peptide alone, the immune stimulatory ability of the resulting peptide-AuNCs can not only be retained, but can also be efficaciously enhanced. Moreover, through a dual-delivery of antigen peptides and cytosine-phosphate-guanine (CpG) oligodeoxynucleotides (ODNs), the as-prepared peptide-AuNC-CpG conjugates can also act as smart self-vaccines to assist in the generation of high immunostimulatory activity, and be applied as a probe for intracellular imaging. Both in vitro and in vivo studies provide strong evidence that the AuNC-based vaccines may be utilized as safe and efficient immunostimulatory agents that are able to prevent and/or treat a variety of ailments.
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