Journal
NANOSCALE
Volume 7, Issue 41, Pages 17249-17253Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr05459a
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Funding
- NTU-Northwestern Institute for Nanomedicine
- National Research Foundation Singapore [NRF-CRP13-2014-05]
- National Medical Research Council Singapore [NMRC/CBRG/0036/2013]
- Ministry of Education Singapore [MOE2013-T2-2-107]
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Heterogeneous Au-Fe3O4 dumbbell nanoparticles (NPs) are composed of Au NPs and Fe3O4 NPs that bring in optical and magnetic properties respectively. This article reports the engineering of Au-Fe3O4 NPs as gene carriers for magnetic gene transfection as well as contrast agents for micro-optical coherence tomography (mu OCT). As a proof-of-concept, Au-Fe3O4 NPs are used to deliver the green fluorescent protein to HEK 293T cells and their entrance into the cells is monitored through mu OCT.
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