Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 131, Issue 6, Pages 1528-+Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2013.01.001
Keywords
Body mass index; rapid growth; asthma; child; latent growth mixture model; European birth cohorts; Global Allergy and Asthma European Network
Categories
Funding
- Global Allergy and Asthma European Network (GA2LEN) under the Sixth Framework Programme for Research of the European Union [FOOD-CT-2004-506378]
- Kompetenznetz Adipositas (Competence Network Obesity)
- Federal Ministry of Education and Research of Germany [FKZ: 01GI0826]
- Munich Center of Health Sciences (MCHEALTH) as part of the Munich Ludwigs-Maximilians-Universitat LMU innovative
- Federal Ministry for Education, Science, Research, and Technology [01 EE 9401-4, 01 EG 9705/2, 01EG9732]
- Federal Ministry of Environment (IUF) [FKZ 20462296, FKS 20462296]
- German Federal Ministry of Education and Research (BMBF) [07015633, 07 ALE 27, 01EE9405/5, 01EE9406]
- German Research Foundation (DFG) [KE 1462/2-1]
- Danish National Ministry of Health
- Netherlands Organization for Health Research and Development
- Netherlands Organization for Scientific Research
- Netherlands Asthma Fund
- Netherlands Ministry of Spatial Planning Housing, and the Environment
- Netherlands Ministry of Health, Welfare, and Sport
- Research Foundation Flanders (FWO, Fonds Wetenschappelijk Onderzoek Vlaanderen)
- Ministry of Health of the Flemish Community
- Fondo de Investigacion Sanitaria, ISCIII, Ministero de Sanidad y Servicios Sociales, Spain [FIS 95/0314, FIS 96/0799, FIS 00/0021, FIS 03/0296]
- Istituto Superiore di Sanita [CIRT-1999 SGR 00241]
- COLT Foundation
- Fifth European Program [QLK4-CT-2000-00263]
- Fondo de Investigacion Sanitaria, ISCIII, Ministerio de Sanidad y Servicios Sociales, Spain [G03/176, CB06/02/0041, 97/0588, 00/0021-2, PI061756, PS0901958]
- EC [QLK4 CT 2000 00263]
- Fundacion Roger Torne
- Charite Berlin
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Background: The causal link between body mass index (BMI) or obesity and asthma in children is still being debated. Analyses of large longitudinal studies with a sufficient number of incident cases and in which the time-dependent processes of both excess weight and asthma development can be validly analyzed are lacking. Objective: We sought to investigate whether the course of BMI predicts incident asthma in childhood. Methods: Data from 12,050 subjects of 8 European birth cohorts on asthma and allergies were combined. BMI and doctor-diagnosed asthma were modeled during the first 6 years of life with latent growth mixture modeling and discrete time hazard models. Subpopulations of children were identified with similar standardized BMI trajectories according to age-and sex-specific World Health Organization (WHO) child growth standards and WHO growth standards for school aged children and adolescents for children up to age 5 years and older than 5 years, respectively (BMI-SDS). These types of growth profiles were analyzed as predictors for incident asthma. Results: Children with a rapid BMI-SDS gain in the first 2 years of life had a higher risk for incident asthma up to age 6 years than children with a less pronounced weight gain slope in early childhood. The hazard ratio was 1.3 (95% CI, 1.1-1.5) after adjustment for birth weight, weight-for-length at birth, gestational age, sex, maternal smoking in pregnancy, breastfeeding, and family history of asthma or allergies. A rapid BMI gain at 2 to 6 years of age in addition to rapid gain in the first 2 years of life did not significantly enhance the risk of asthma. Conclusion: Rapid growth in BMI during the first 2 years of life increases the risk of asthma up to age 6 years.
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