Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 129, Issue 3, Pages 635-645Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2011.10.029
Keywords
IgE; atopic asthma; allergic rhinitis; memory B cells; plasma cells
Categories
Funding
- Wellcome Trust
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- MRC [G0501494, G1100090, G0400106] Funding Source: UKRI
- Medical Research Council [G0400106, G0501494, G1000758, G1000758B, G1100090] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10212] Funding Source: researchfish
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Allergic asthma and allergic rhinitis/conjunctivitis are characterized by a T(H)2-dominated immune response associated with increased serum IgE levels in response to inhaled allergens. Because IgE is a key player in the induction and maintenance of allergic inflammation, it represents a prime target for therapeutic intervention. However, our understanding of IgE biology remains fragmentary. This article puts together our current knowledge on IgE in allergic airway diseases with a special focus on the identity of IgE-secreting cells (who''), their location (where''), and the circumstances in which they are induced (when''). We further consider the therapeutic implications of the insights gained. (J Allergy Clin Immunol 2012; 129: 635-45.)
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