Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 11, Issue 7, Pages 1677-1688Publisher
ELSEVIER
DOI: 10.1016/j.nano.2015.05.002
Keywords
Chlorogenic acid; Gold nanoparticles; Green synthesis; Inflammation; NF-kappa B
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Korean Government
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2012R1A1A2042224]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2013R1A1A1059709, 2010-18282]
- National Research Foundation of Korea [2013R1A1A1059709, 2010-0018282, 2012R1A1A2042224] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Here we developed a novel green synthesis method for gold nanoparticles (CGA-AuNPs) using chlorogenic acid (CGA) as reductants without the use of other chemicals and validated the anti-inflammatory efficacy of CGA-AuNPs in vitro and in vivo. The resulting CGA-AuNPs appeared predominantly spherical in shape with an average diameter of 22.25 +/- 4.78 nm. The crystalline nature of the CGA-AuNPs was confirmed by high-resolution X-ray diffraction and by selected-area electron diffraction analyses. High-resolution liquid chromatography/electrospray ionization mass spectrometry revealed that the caffeic acid moiety of CGA forms quinone structure through a two-electron oxidation causing the reduction of Au3+ to Au-0. When compared to CGA, CGA-AuNPs exhibited enhanced anti-inflammatory effects on NF-kappa B-mediated inflammatory network, as well as cell adhesion. Collectively, green synthesis of CGA-AuNPs using bioactive reductants and mechanistic studies based on mass spectrometry may open up new directions in nanomedicine and CGA-AuNPs can be an anti-inflammatory nanomedicine for future applications. From the Clinical Editor: Gold nanoparticles (Au NPs) have been shown to be very useful in many applications due to their easy functionalization capability. In this article, the authors demonstrated a novel method for the synthesis of gold nanoparticles using chlorogenic acid (CGA) as reductants. In-vitro experiments also confirmed biological activity of the resultant gold nanoparticles. Further in-vivo studies are awaited. (C) 2015 Elsevier Inc. All rights reserved.
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