Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 125, Issue 1, Pages 4-13Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2009.11.027
Keywords
Atopic dermatitis; filaggrin; epidermal barrier; Staphylococcus aureus; herpes simplex virus; superantigens; T regulatory cells; eczema herpeticum; antimicrobial peptides; probiotics
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Funding
- National Institutes of Health/National Institute of Allergy and Infectious Diseases [N01 AI 40029, 40030, AR41256]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [N01AI040029] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR041256] Funding Source: NIH RePORTER
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Atopic dermatitis (AD) is a common complex disease that frequently follows a chronic relapsing course and affects the quality of life of patients and families in a significant manner. New insights into the pathophysiology of AD point to an important role of structural abnormalities in the epidermis combined with immune dysregulation. Patients with AD have a unique predisposition to colonization or infection by a number of microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. A multipronged approach directed at healing or protecting the skin barrier and addressing the immune dysregulation is necessary to improve the likelihood of successful outcomes. (J Allergy Clin Immunol 2010;125:4-13.)
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