Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 125, Issue 2, Pages 312-318Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2009.12.936
Keywords
Allergic conjunctivitis; allergic inflammation; anaphylaxis; asthma; asthma genetics; atopic dermatitis; eosinophils; food allergy; immediate hypersensitivity; mast cells; nasal polyposis; polymorphisms
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Funding
- Abbott Pharmaceuticals
- National Institutes of Health
- Food Allergy and Anaphylaxis Network
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The year 2009 was marked by rapid progress in understanding cellular and chemical mechanisms in the pathogenesis of asthma and other allergic disorders. Studies published in the Journal of Allergy and Clinical Immunology described advances in our knowledge of signaling molecules and pathways, cytokines, and activation and tolerance in asthma and murine models of this disease; food allergy; anaphylaxis and immediate hypersensitivity; mast cells and their disorders; atopic dermatitis; allergic conjunctivitis; nasal polyposis, and hypereosinophilic syndromes. Additional studies provided novel information about the induction and regulation of allergic inflammation and the genetic determinants of asthma and responsiveness to asthma therapy. Critical features of these studies and their potential effect on human atopic disorders are summarized here. (J Allergy Clin Immunol 2010;125:312-8.)
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