Journal
NANOMEDICINE
Volume 10, Issue 11, Pages 1801-1815Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm.15.30
Keywords
gadolinium; MRI; multimodality; nanoparticles; oncology; radiotherapy; theranostic
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A rapid development of gadolinium-based nanoparticles is observed due to their attractive properties as MRI-positive contrast agents. Indeed, they display high relaxivity, adapted biodistribution and passive uptake in the tumor thanks to enhanced permeability and retention effect. In addition to these imaging properties, it has been recently shown that they can act as effective radiosensitizers under different types of irradiation (radiotherapy, neutron therapy or hadron therapy). These new therapeutic modalities pave the way to therapy guided by imaging and to personalized medicine.
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