Journal
NANOMEDICINE
Volume 10, Issue 2, Pages 205-214Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.14.86
Keywords
albumin; drug release; in vivo distribution; metabolism; nanoparticles; protein corona; stability
Funding
- National Natural Science Foundation of China [31170929, 81201211, 81402860]
- Ministry of Education of China [20130181110012, 20110181120071]
- Foundation of State Key Laboratory of Oral Diseases [SKLOD201405]
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Aims: The long-term efficacy of nanoparticles is limited by their rapid metabolism in tissues. In this work, we aim to enhance nanoparticle biostability by preforming a bovine serum albumin (BSA) corona. Materials & methods: A BSA corona was formed by incubating poly-3-hydroxybutyrate-co-3-hydroxyhexanoate nanoparticles with BSA solution and confirmed by SDS-PAGE and x-ray photoelectron spectroscopy. The impacts of the BSA corona on the drug release, biostability and biodistribution of nanoparticles were investigated. Results: In the presence of the BSA corona, the drug release (coumarin-6 was used as the model drug) of nanoparticles was significantly slower and their stability in liver homogenate and in organs was enhanced. Conclusion: Preformation of a BSA corona may be a promising approach for enhancing drug biostability and for developing long-acting nanoparticle formulations.
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