Journal
NANOMEDICINE
Volume 10, Issue 3, Pages 447-463Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm.14.179
Keywords
carrier-mediated agents; clearance; Doxil; nanoparticles; pharmacokinetics; S-CKD602
Funding
- National Cancer Institute of the NIH [U54CA151652]
- University of North Carolina University Cancer Research Fund
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Major advances in carrier-mediated agents, which include nanoparticles, nanosomes and conjugates, have revolutionized drug delivery capabilities over the past decade. While providing numerous advantages, such as greater solubility, duration of exposure and delivery to the site of action over their small-molecule counterparts, there is substantial variability in systemic clearance and distribution, tumor delivery and pharmacologic effects (efficacy and toxicity) of these agents. This review provides an overview of factors that affect the pharmacokinetics and pharmacodynamics of carrier-mediated agents in preclinical models and patients.
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