Journal
NANOMEDICINE
Volume 10, Issue 9, Pages 1423-1437Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.14.113
Keywords
biodistribution; dendrimers; G5-Gd-BnDOTA; lymphatic imaging; MRI c-ontrast agent; PAMAM G5
Funding
- National Cancer Institute, NIH [HHSN261200800001E]
- NIH, National Cancer Institute, Center for Cancer Research
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [ZICHL005090] Funding Source: NIH RePORTER
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Aims: To demonstrate the use of gadolinium (Gd)-labeled dendrimers as lymphatic imaging agents and establish the long-term biodistribution (90-day) of this type of agent in mice. Materials & methods: A G5-Gd-BnDOTA dendrimer was prepared and injected into mice and monkeys for MR lymphangiography, and long-term biodistribution of the conjugate was studied. Results: Administration of G5-Gd-BnDOTA in mice demonstrated a rapid uptake in the deep lymphatic system while injection in monkeys showed enhanced internal iliac nodes, indicating its general utility for lymphatic tracking. Biodistribution studies to 90 days showed that gadolinium conjugate is slowly being eliminated from the liver and other organs. Conclusion: The use of G5-Gd-BnDOTA holds great promise for lymphatic imaging, but its slow clearance from the body might hamper its eventual clinical translation.
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