Journal
NANOMEDICINE
Volume 10, Issue 7, Pages 1149-1163Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.14.213
Keywords
antitumor efficiency; drug delivery; nanoparticles; phenylboronic acid; sialic acid
Funding
- National Natural Science Foundation of China [51033002, 51273090, 21474045]
- Program for Changjiang Scholars and Innovative Research Team in University
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Significant efforts have recently been made to develop nanoscaled boron-containing delivery systems for improving drug delivery in cancer therapy. On one hand, borate ester chemistry has shown importance in ligand-mediated tumor targeting owing to the recognition ability of boronic acid to polyol residues in cell membranes. In particular, the phenylboronic acid-functionalized nanocarriers for specific targeting to sialic acid groups which are overexpressed on tumor cells have made great achievements. On the other hand, nanoscaled boron neutron capture therapy agents show growing potential in efficiently transporting boron to tumor. The current review outlines the recent developments in the application of borate ester chemistry in tumor targeting by nanoparticles, then summarizes recent work on the development of boron-based nanomaterials as boron neutron capture therapy agents.
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