Journal
NANOMEDICINE
Volume 10, Issue 12, Pages 1959-1971Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.15.28
Keywords
antimicrobial agent; drug delivery system; infection; nanofiber
Funding
- Chang Gung Memorial Hospital [CMRPG3C0411, CMRPD290072]
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Nanotechnology has gained an increased interest in several different areas of biotechnology including the drug delivery via nanofibers. Self-assembly, phase separation and electrospinning can all be used to successfully generate nanofibers with sizes well within the range of those of the fibers present in the native extracellular matrix (50-500 nm). In this article, the authors introduced the most popular applications of nanofibers related to the delivery of antimicrobial agents for infectious diseases. To date, only a few in-vivo studies are available at present to demonstrate its clinical potential; most of the studies are of exploratory nature and rely mostly on in-vitro experiments. Therefore, further advancement in the production and clinical performance of drug-loaded nanofibrous matrices seems necessary.
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