Journal
NANOMEDICINE
Volume 10, Issue 18, Pages 2847-2859Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm.15.107
Keywords
bombesin; cytotoxicity; docetaxel; nanoparticles; pharmacokinetics; prostate cancer
Funding
- IICT-RMIT Research Centre
- Council of Scientific and Industrial Research (CSIR), New Delhi
- CSIR [CSC 0302]
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Aim: Bombesin (BBN)-conjugated polymeric nanoparticles to target docetaxel (DTX) to prostate cancer cells that overexpress gastrin-releasing peptides receptors. Materials & methods: In vitro cytotoxicity, uptake of nanoparticles and inhibition of cell migration were assessed against human prostate cancer cells. Preclinical pharmacokinetic and tissue-distribution studies of nanoparticles were performed in Balb/c mice and results compared with the marketed formulation Taxotere (R). Results: BBN-conjugated DTX-loaded nanoparticles exhibited higher cytotoxicity, inhibition of cell migration and colony formation than non-targeted nanoparticles or DTX alone. More BBN-conjugated nanoparticles were taken up at a faster rate than unconjugated nanoparticles. In vivo, this drug delivery improved pharmacokinetics of DTX by increasing mean residence time and decreasing clearance. Conclusion: This study provides an alternate approach for polysorbate-free delivery of DTX, with improved in vivo performance.
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