Journal
NANO TODAY
Volume 10, Issue 6, Pages 759-776Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2015.11.009
Keywords
Endothelium; Nanomedicine; Endothelial disorder; Diabetes; Atherosclerosis; Cancer
Categories
Funding
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health (NIH), as a Program of Excellence in Nanotechnology (PEN) Award [HHSN268201000045C]
- National Cancer Institute Grant [CA151884]
- David H. Koch-Prostate Cancer Foundation Award in Nanotherapeutics
- ACTSI Emory/GA Tech Regenerative Engineering and Medicine (REM) Seed Grant
- Center for Pediatric Nanomedicine (CPN) of Children's Healthcare of Atlanta Seed Grant
- American Heart Association Scientist Development Grant [15SDG25080314]
- National Institute Of Neurological Disorders and Stroke of the National Institutes of Health [R21NS091682]
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The endothelium lines the internal surfaces of blood and lymphatic vessels and has a critical role in maintaining homeostasis. Endothelial dysfunction is involved in the pathology of many diseases and conditions, including disorders such as diabetes, cardiovascular diseases, and cancer. Given this common etiology in a range of diseases, medicines targeting an impaired endothelium can strengthen the arsenal of therapeutics. Nanomedicine - the application of nanotechnology to healthcare - presents novel opportunities and potential for the treatment of diseases associated with an impaired endothelium. This review discusses therapies currently available for the treatment of these disorders and highlights the application of nanomedicine for the therapy of these major disease complications. (C) 2015 Elsevier Ltd. All rights reserved.
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