Journal
NANO RESEARCH
Volume 9, Issue 1, Pages 139-148Publisher
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-015-0898-4
Keywords
near-infrared (NIR)-activable; drug delivery; aptamer; gold nanorods; single-walled carbon nanotubes
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Funding
- National Natural Science Foundation of China [51222203, 51132006]
- National Basic Research Program of China [2011CB911002, 2012CB932601]
- Jiangsu Natural Science Fund for Distinguished Young Scholars
- Macao Science and Technology Development Fund [062/2013/A2]
- University of Macau [MYRG2014-00033-ICMS-QRCM, MRG004/CMW/2014/ICMS]
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Stimuli-activated targeted delivery systems for highly accurate treatment of tumors have received considerable attention in recent years. Herein, we reveal a light-activable cancer-targeting strategy that uses a complementary DNA sequence to hybridize and mask sgc8 aptamers conjugated onto photothermal agents such as gold nanorods or single-walled carbon nanotubes (SWNTs). Upon exposure to near-infrared (NIR) laser, localized photothermal heating of the surface of those nano-agents results in dehybridization of the double-stranded DNA and uncaging of the aptamer sequence to allow specific cancer-cell targeting. Utilizing doxorubicin-loaded SWNTs as a model system, targeted drug delivery to cancer cells activated by NIR light was achieved. This work demonstrates the concept of NIR-activable tumor-targeting delivery systems with controllable cancer-cell binding to potentially enable highly specific and efficient cancer therapy.
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