Journal
NANO LETTERS
Volume 15, Issue 10, Pages 6672-6676Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.5b02502
Keywords
DNA origami; light-driven; DNA motor; high-speed AFM; single molecule analysis
Categories
Funding
- MEXT [24104002]
- JSPS KAKENHI [15H03837, 24225005, 26620133]
- Sekisui Chemical Research Grant
- Kurata Memorial Hitachi Science and Technology Foundation
- National Key Scientific Program of China [2011CB911000]
- NSFC [NSFC 21221003, NSFC 21327009]
- China National Instrumentation Program [2011YQ03012412]
- National Institutes of Health [GM079359, CA133086]
- Grants-in-Aid for Scientific Research [15H03837, 24104002, 26620133] Funding Source: KAKEN
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A light-driven artificial molecular nanomachine was constructed based on DNA scaffolding. Pyrene-modified walking strands and disulfide bond-connected stator strands, employed as anchorage sites to support walker movement, were assembled into a 2D DNA tile. Pyrene molecules excited by photoirradiation at 350 nm induced cleavage of disulfide bond-connected stator strands, enabling the DNA walker to migrate from one cleaved stator to the next on the DNA tile. The time-dependent movement of the walker was observed and the entire walking process of the walker was characterized by distribution of the walker-stator duplex at four anchorage sites on the tile under different irradiation times. Importantly, the light-fuelled mechanical movements on DNA tile were first visualized in real time during UV irradiation using high-speed atomic force microscopy (HS-AFM).
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