Journal
NANO LETTERS
Volume 15, Issue 5, Pages 2938-2944Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl5047494
Keywords
Liposome; Membrane vesicle; nanomedicine; photosensitizer; spheroid
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Funding
- Basic Science Research Program through the National Research Foundation - Ministry of Science, ICT & Future Planning, Republic of Korea [NRF-2012R1A1A1011058]
- Global Frontier Project through the National Research Foundation - Ministry of Science, ICT & Future Planning, Republic of Korea [NRF-2013M3A6A4072541]
- Pioneer Research Center Program through the National Research Foundation - Ministry of Science, ICT & Future Planning, Republic of Korea [NRF-2014M3C1A3051460]
- National Research Foundation of Korea [2014M3C1A3051470] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Natural membrane vesicles (MVs) derived from various types of cells play an essential role in transporting biological materials between cells. Here, we show that exogenous compounds are packaged in the MVs by engineering the parental cells via liposomes, and the MVs mediate autonomous intercellular migration of the compounds through multiple cancer cell layers. Hydrophobic compounds delivered selectively to the plasma membrane of cancer cells using synthetic membrane fusogenic liposomes were efficiently incorporated into the membrane of MVs secreted from the cells and then transferred to neighboring cells via the MVs. This liposome-mediated MV engineering strategy allowed hydrophobic photosensitizers to significantly penetrate both spheroids and in vivo tumors, thereby enhancing the therapeutic efficacy. These results suggest that innate biological transport systems can be in situ engineered via synthetic liposomes to guide the penetration of chemotherapeutics across challenging tissue barriers in solid tumors.
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