Journal
NANO LETTERS
Volume 16, Issue 1, Pages 177-181Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.5b03440
Keywords
Phototriggering; liposome; gold nanorod; local anesthesia; tetrodotoxin
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Funding
- National Institutes of Health (NIH) [GM073626]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM073626] Funding Source: NIH RePORTER
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We report a phototriggerable formulation enabling in vivo repeated and on-demand anesthesia with minimal toxicity. Gold nanorods (GNRs) that can convert near-infrared (NIR) light into heat were attached to liposomes (Lip-GNRs), enabling light-triggered phase transition of their lipid bilayers with a consequent release of payload. Lip-GNRs containing the site 1 sodium channel blocker tetrodotoxin and the alpha(2)-adrenergic agonist dexmedetomidine (Lip-GNR-TD) were injected subcutaneously in the rat footpad. Irradiation with an 808 nm continuous wave NIR laser produced on-demand and repeated infiltration anesthesia in the rat footpad in proportion to the irradiance, with minimal toxicity. The ability to achieve on-demand and repeated local anesthesia could be very beneficial in the management of pain.
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