Journal
NANO LETTERS
Volume 15, Issue 12, Pages 8311-8315Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.5b03935
Keywords
Enzymes; catalysis; microparticles; micromotors; diffusion; chemotaxis
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Funding
- Penn State MRSEC under NSF [DMR-1420620]
- NSF CAREER [CBET-1055284]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1055284] Funding Source: National Science Foundation
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Active biocompatible systems are of great current interest for their possible applications in drug or antidote delivery at specific locations. Herein, we report the synthesis and study of self-propelled microparticles powered by enzymatic reactions and their directed movement in substrate concentration gradient. Polystyrene micropartides were functionalized with the enzymes urease and catalase using a biotin streptavidin linkage procedure. The motion of the enzyme-coated particles was studied in the presence of the respective substrates, using optical microscopy and dynamic light scattering analysis. The diffusion of the particles was found to increase in a substrate concentration dependent manner. The directed chemotactic movement of these enzyme-powered motors up the substrate gradient was studied using three-inlet microfluidic channel architecture.
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