Journal
NANO LETTERS
Volume 15, Issue 4, Pages 2249-2256Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl504044p
Keywords
nanomedicine; X-PDT; nanoscintillator; radioluminescence nanophosphors; singlet oxygen; cancer treatment
Categories
Funding
- NCI/NTH R00 [5R00CA153772]
- UGA-GRU seed grant
- NSF CAREER grant [CAREER DMR-0955908]
- intramural research program of the National Institute of Biomedical Imaging and Bioengineering (NIBIB)
- Elsa U. Pardee Foundation Award
- National Basic Research Program of China [2015CB931800]
- National Natural Science Foundation of China [81130028, 31210103913]
- Key Grant Project of Heilongjiang Province [GA12C302]
- Ph.D. Programs Foundation of Ministry of Education of China [201123071100203]
- Key Laboratory of Molecular Imaging Foundation (College of Heilongjiang Province)
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [0955908] Funding Source: National Science Foundation
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Photodynamic therapy is a promising :treatment method, but its applications are limited by the shallow penetration of visible light Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach That allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a Core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.
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