Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 66, Issue 41, Pages 10663-10685Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.8b04104
Keywords
cancer; metabolism; energetic and biosynthetic pathways; tumor cells; phenolics; isoprenoids; alkaloids
Funding
- national funds through the FCT/MEC [FCT UID/CTM/50011/2013, UID/AGR/00115/2013]
- European Regional Development Fund (FEDER)
- FEDER through COMPETE [PTDC/AGR-FOR/3187/2012]
- national funds through FCT
- European Union Framework Programme for Research and Innovation HORIZON 2020 under the TEAMING [739572]
- FCT [SFRH/BD/98635/2013]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/98635/2013, PTDC/AGR-FOR/3187/2012] Funding Source: FCT
Ask authors/readers for more resources
Recognition of neoplastic metabolic reprogramming as one of cancer's hallmarks has paved the way for developing novel metabolism-targeted therapeutic approaches. The use of plant-derived natural bioactive compounds for this endeavor is especially promising, due to their diverse structures and multiple targets. Hence, over the past decade, a growing number of studies have assessed the impact of phytochemicals on tumor cell metabolism, aiming at improving current knowledge on their mechanisms of action and, at the same time, evaluating their potential as anti-cancer metabolic modulators. In this Review, we focus on three classes of plant-derived compounds with promising anti-cancer activity-phenolic compounds, isoprenoids, and alkaloids-to describe their effects on major energetic and biosynthetic pathways of human tumor cells. Such a comprehensive and integrated account of the ability of these compounds to hit different metabolic targets is expected to contribute to the rational design and critical assessment of novel anti-cancer therapies based on natural-product mediated metabolic reprogramming.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available