Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 62, Issue 7, Pages 1581-1589Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf4053012
Keywords
Ganoderma atrum polysaccharide; antitumor; apoptosis; CT26; immunomodulatory
Funding
- Key Program of National Natural Science Foundation of China [31130041]
- National Natural Science Foundation of China [31071532]
- National Key Technology R & D Program of China [2012BAD33B06]
- Program for New Century Excellent Talents in University [NCET-12-0749]
- Research Project of State Key Laboratory of Food Science and Technology [SKLF-ZZA-201301, SKLF-TS-201107]
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Ganoderma is a precious health-care edible medicinal fungus in China. A novel Ganoderma atrum polysaccharide (PSG-1) is the main bioactive component. We investigated the antitumor effect and molecular mechanisms of PSG-1. It exhibited no significant effect on cell proliferation directly. In contrast, administration of PSG-1 markedly suppressed tumor growth in CT26 tumor-bearing mice. It was observed that PSG-1 caused apoptosis in CT26 cells. Apoptosis was associated with loss of mitochondrial membrane potential, enhancement of mitochondrial cytochrome c release and intracellular ROS production, elevation of p53 and Box expression, downregulation of Bcl-2, and the activation of caspase-9 and -3. Moreover, PSG-1 enhanced immune organ index and promoted lymphocyte proliferation as well as cytokine levels in serum. Taken together, our data indicate that PSG-1 has potential antitumor activity in vivo by inducing apoptosis via mitochondria-mediated apoptotic pathway and enhances host immune system function. Therefore, PSG-1 could be a safe and effective antitumor, bioactive agent or functional food.
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