Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 62, Issue 32, Pages 8214-8220Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf5018725
Keywords
ionic liquid microemulsion; cross-linking; starch nanoparticles; drug loading; drug release
Funding
- National Natural Science Foundation of China [21376097, 21004023]
- program for New Century Excellent Talents in University [NCET-13-0212]
- Guangdong Natural Science Foundation [S2013010012318]
- Key Project of Science and Technology of Guangdong Province [2012B091100443, 2012B091100047]
- Fundamental Research Funds for the Central Universities, SCUT [2013ZZ0070]
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An ionic liquid microemulsion consisting of 1-butyl-3-methylimidazolium hexafluorophosphate ([Bmim]PF6), surfactant TX-100, 1-butanol, and water was prepared. The water-in-[Bmim]PF6 (W/IL), bicontinuous, and [Bmim]PF6-in-water (IL/W) microregions of the microemulsion were identified by conductivity measurements. Starch nanoparticles with a mean diameter of 91.4 nm were synthesized with epichlorohydrin as cross-linker through W/IL microemulsion cross-linking reaction at 50 degrees C for 4 h. Fourier transform infrared spectroscopy (FTIR) data demonstrated the formation of cross-linking bonds in starch molecules. Scanning electron microscopy (SEM) revealed that starch nanoparticles were spherical and that some particles showed aggregation formation. Furthermore, drug loading and releasing properties of starch nanoparticles were investigated with mitoxantrone hydrochloride as a drug model. This work provides an efficient and environmentally friendly approach for the preparation of starch nanoparticles, which is beneficial to their further application.
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