Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 62, Issue 28, Pages 6687-6698Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf501924y
Keywords
maple syrup; extract; nutraceutical; phytochemicals; biological; safety
Funding
- Agriculture and Agri-Food Canada (AAFC)
- Federation of Maple Syrup Producers of Quebec (FPAQ)
- AAFC
- FPAQ
- National Science Foundation EPSCoR [EPS-1004057]
- National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) [P20RR016457]
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Maple syrup has nutraceutical potential given the macronutrients (carbohydrates, primarily sucrose), micronutrients (minerals and vitamins), and phytochemicals (primarily phenolics) found in this natural sweetener. We conducted compositional (ash, fiber, carbohydrates, minerals, amino acids, organic acids, vitamins, phytochemicals), in vitro biological, and in vivo safety (animal toxicity) studies on maple syrup extracts (MSX-1 and MSX-2) derived from two declassified maple syrup samples. Along with macronutrient and micronutrient quantification, thirty-three phytochemicals were identified (by HPLC-DAD), and nine phytochemicals, including two new compounds, were isolated and identified (by NMR) from MSX. At doses of up to 1000 mg/kg/day, MSX was well tolerated with no signs of overt toxicity in rats. MSX showed antioxidant (2,2-diphenyl-1-picrylhydrazyl (DPPH) assay) and anti-inflammatory (in RAW 264.7 macrophages) effects and inhibited glucose consumption (by HepG2 cells) in vitro. Thus, MSX should be further investigated for potential nutraceutical applications given its similarity in chemical composition to pure maple syrup.
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